|
rs4994
|
|
|
0.030 |
GeneticVariation |
BEFREE |
β3-Adrenergic receptor (ADRB3) Trp64Arg polymorphism is associated with atherogenic risk factors that include weight gain, insulin resistance, and diabetes.
|
24658877 |
2014 |
|
rs13266634
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ZnT8 Arg325Trp polymorphism influences zinc transporter expression and cytokine production in PBMCs from patients with diabetes.
|
30142362 |
2018 |
|
rs1364181648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ZnT8 Arg325Trp polymorphism influences zinc transporter expression and cytokine production in PBMCs from patients with diabetes.
|
30142362 |
2018 |
|
rs13266634
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Zinc supplementation appears to affect the early insulin response to glucose differentially by rs13266634 genotype and could be beneficial for diabetes prevention and/or treatment for some individuals based on SLC30A8 variation.
|
25348609 |
2015 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Younger ages of onset of diabetes as well as a longer duration of the disease were detected in patients carrying at least one C282Y allele (p = 0.007).
|
15347835 |
2004 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
When these 6 traits were included in a multivariate analysis, body mass index, systolic and diastolic blood pressures, triglyceride levels, and glucose concentration remained significantly associated with the P12A variant (P < 0.05), whereas the effect of P12A on liability for diabetes was not significant.
|
11158005 |
2001 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
When these 6 traits were included in a multivariate analysis, body mass index, systolic and diastolic blood pressures, triglyceride levels, and glucose concentration remained significantly associated with the P12A variant (P < 0.05), whereas the effect of P12A on liability for diabetes was not significant.
|
11158005 |
2001 |
|
rs137853240
|
|
|
0.090 |
GeneticVariation |
BEFREE |
When participants were stratified by baseline smoking status, HNF1A G319S carriers who were active smokers had increased risk of developing diabetes (OR 6.91 [95% CI 3.38-14.12]), while the association was attenuated to non-significance among non-smokers (1.11 [0.40-3.08]).
|
21208426 |
2011 |
|
rs6850
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Welchs two-sample t test indicated an association of SNP rs6850: A > G, located at the 5' UTR region with increased plasma levels of cyclophilin A in patients with coronary artery disease and with coronary artery disease associated with diabetes.
|
26702934 |
2016 |
|
rs1022113606
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We used the prospective Copenhagen General Population Study and Copenhagen City Heart Study and genotyped 95,871 individuals for the rs1799895 R213G variation in the SOD3 gene, of which 4498 had diabetes.
|
26844281 |
2015 |
|
rs1799895
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We used the prospective Copenhagen General Population Study and Copenhagen City Heart Study and genotyped 95,871 individuals for the rs1799895 R213G variation in the SOD3 gene, of which 4498 had diabetes.
|
26844281 |
2015 |
|
rs738409
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We used instrumental variable analysis based on two single nucleotide polymorphism (SNPs) HSD17B13/MAPK10 (rs6834314) and PNPLA3/SAMM50 (rs738409) to assess the associations of ALT (U/L) with IHD, diabetes and other CVD risk factors in the Guangzhou Biobank Cohort Study (GBCS).
|
28007909 |
2017 |
|
rs6834314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We used instrumental variable analysis based on two single nucleotide polymorphism (SNPs) HSD17B13/MAPK10 (rs6834314) and PNPLA3/SAMM50 (rs738409) to assess the associations of ALT (U/L) with IHD, diabetes and other CVD risk factors in the Guangzhou Biobank Cohort Study (GBCS).
|
28007909 |
2017 |
|
rs118081497
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We therefore propose that the N1072K variant of the EEA1 gene is a candidate mutation for susceptibility to diabetes in the Japanese population.
|
23499280 |
2013 |
|
rs6548238
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We tested the hypothesis that the ADRB2rs1800888(Thr164Ile) polymorphism associates with risk of obesity and diabetes and compared effect sizes with those of FTO(rs9939609), MC4R(rs17782313), and TMEM18(rs6548238).
|
22466342 |
2012 |
|
rs17782313
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We tested the hypothesis that the ADRB2rs1800888(Thr164Ile) polymorphism associates with risk of obesity and diabetes and compared effect sizes with those of FTO(rs9939609), MC4R(rs17782313), and TMEM18(rs6548238).
|
22466342 |
2012 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We tested the hypothesis that the ADRB2rs1800888(Thr164Ile) polymorphism associates with risk of obesity and diabetes and compared effect sizes with those of FTO(rs9939609), MC4R(rs17782313), and TMEM18(rs6548238).
|
22466342 |
2012 |
|
rs1800888
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We tested the hypothesis that the ADRB2rs1800888(Thr164Ile) polymorphism associates with risk of obesity and diabetes and compared effect sizes with those of FTO(rs9939609), MC4R(rs17782313), and TMEM18(rs6548238).
|
22466342 |
2012 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We tested the effect-modifying role of Pro12Ala on the 1 year change in obesity-related traits in a randomised clinical trial of treatment with metformin (n = 989), troglitazone (n = 363) or lifestyle modification (n = 1,004) vs placebo (n = 1,000) for diabetes prevention in high-risk individuals.
|
17898990 |
2007 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We tested the effect-modifying role of Pro12Ala on the 1 year change in obesity-related traits in a randomised clinical trial of treatment with metformin (n = 989), troglitazone (n = 363) or lifestyle modification (n = 1,004) vs placebo (n = 1,000) for diabetes prevention in high-risk individuals.
|
17898990 |
2007 |
|
rs3798220
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We tested associations of tertiles of lipoprotein(a) concentration in plasma and two LPA single-nucleotide polymorphisms ([SNPs] rs10455872 and rs3798220) with all-cause mortality and cardiovascular mortality by Cox regression analysis and with severity of disease by generalised linear modelling, with and without adjustment for age, sex, diabetes diagnosis, systolic blood pressure, BMI, smoking status, estimated glomerular filtration rate, LDL-cholesterol concentration, and use of lipid-lowering therapy.
|
28566218 |
2017 |
|
rs10455872
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We tested associations of tertiles of lipoprotein(a) concentration in plasma and two LPA single-nucleotide polymorphisms ([SNPs] rs10455872 and rs3798220) with all-cause mortality and cardiovascular mortality by Cox regression analysis and with severity of disease by generalised linear modelling, with and without adjustment for age, sex, diabetes diagnosis, systolic blood pressure, BMI, smoking status, estimated glomerular filtration rate, LDL-cholesterol concentration, and use of lipid-lowering therapy.
|
28566218 |
2017 |
|
rs10830963
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We tested rs10830963 for association with cross-sectional diabetes-related traits in up to 1,383 individuals or with rate of change in the same phenotypes over a 3-5 year follow-up in up to 374 individuals from the family-based BetaGene study of Mexican Americans.
|
24728128 |
2014 |
|
rs7903146
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied 120 individuals of whom one-half were homozygous for the diabetes-associated allele TT at rs7903146 and one-half were homozygous for the protective allele CC.
|
26525881 |
2016 |
|
rs7756992
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We showed association of the minor allele C of rs10946398 (Odds Ratio (OR) = 1.21, 95% CI = 1.04-1.4, P = 0.016), allele C of rs7754840 (OR = 1.18, 95% CI = 1.01-1.37, P = 0.038), and allele G of rs7756992 (OR = 1.21, 95% CI = 1.04-1.42, P = 0.017) with higher diabetes risk thereby replicating the predisposing role of CDKAL1 in etiology of T2D.
|
21611789 |
2011 |